HermesC: RF wireless low-power neural recording system for freely behaving primates

Neural prosthetics for motor systems is a rapidly growing field with the potential to provide treatment for amputees or patients suffering from neurological injury and disease. To determine whether a physically active patient such as an amputee can take advantage of these systems, we seek to develop an animal model of freely moving humans. Therefore, we have developed and tested HermesC, a system for recording neural activity from electrode arrays implanted in rhesus monkeys and transmitting this data wirelessly. This system is based on the integrated neural interface (INI) microchip, which amplifies, digitizes, and transmits neural data across a ∼900 MHz wireless channel. The wireless transmission has a range of ∼4 m in free space. All together, this device consumes 11.7 mA from a 4.0 V lithium ion battery pack for a total of 46.8 mW. To test the performance, the device was used to record and telemeter one channel of broadband neural data at 15.7 kSps from one monkey doing various physical activities in a home cage, such as eating, climbing and swinging. The in-band noise of the recorded neural signal is 34 μVrms, which is low enough to allow the detection of neural units on an active electrode. This system can be readily upgraded to use future generations of the INI chip, with circuits providing 96 channels of programmable threshold crossing event data.