Enhancement of cell boundaries in transmission electron microscopy images

Transmission electron microscopy (TEM) is an important modality for the analysis of cellular structures in neurobiology. The computational analysis of neurons entail their segmentation and reconstruction from TEM images. This problem is complicated by the heavily textured nature of cellular TEM images and typically low signal-to-noise ratios. In this paper, we propose a new partial differential equation for enhancing the contrast and continuity of cell membranes in TEM images.