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Systems Biology, IET

Issue 1 • Date January 2008

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Displaying Results 1 - 8 of 8
  • Receptor tyrosine kinases: the emerging tip of systems control

    Publication Year: 2008 , Page(s): 1 - 4
    Save to Project icon | Click to expandAbstract | PDF file iconPDF (112 KB)  

    Receptor tyrosine kinases (RTKs) are transmembrane allosteric enzymes: binding of ligand growth factors to their ectodomains stimulates a cytoplasm-facing tyrosine kinase activity, which initiates a plethora of cellular processes. The enormous complexity of RTK signalling, along with rich involvement in pathologies (e.g. cancer and diabetes), motivated the establishment of the international, multi... View full abstract»

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  • Defining systems biology: through the eyes of a biochemist

    Publication Year: 2008 , Page(s): 5 - 7
    Cited by:  Papers (1)
    Save to Project icon | Click to expandAbstract | PDF file iconPDF (47 KB)  

    What is systems biology, and more importantly what can it do for us? Here is the view of a biochemist who, while working on cellular signal transduction pathways, became increasingly astounded by a highly paradoxical observation. Signal transduction pathways collect numerous types of information in the form of hormones, growth factors or direct cues via contacts with neighbouring cells. These vari... View full abstract»

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  • Integrin-mediated signalling through the MAP-kinase pathway

    Publication Year: 2008 , Page(s): 8 - 15
    Save to Project icon | Click to expandAbstract | PDF file iconPDF (443 KB)  

    The mitogen activated protein (MAP) kinase cascade, leading to extracellular-regulated kinase (ERK) activation, is a key regulator of cell growth and proliferation. The effects of ERK are mediated by differences in ERK signalling dynamics, including magnitude and duration. In vivo, ERK signalling is stimulated by both growth factors and adhesion signals. A model for adhesion-mediated ERK activatio... View full abstract»

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  • Phase tracking and restoration of circadian rhythms by model-based optimal control

    Publication Year: 2008 , Page(s): 16 - 23
    Cited by:  Papers (2)
    Save to Project icon | Click to expandAbstract | PDF file iconPDF (303 KB)  

    Periodic cellular processes and especially circadian rhythms governed by the oscillating expression of a set of genes based on feedback regulation by their products have become an important issue in biology and medicine. The central circadian clock is an autonomous biochemical oscillator with a period close to 24 h. Research in chronobiology demonstrated that light stimuli can be used to delay or ... View full abstract»

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  • Modelling excitable cells using cycle-linear hybrid automata

    Publication Year: 2008 , Page(s): 24 - 32
    Save to Project icon | Click to expandAbstract | PDF file iconPDF (240 KB)  

    Cycle-linear hybrid automata (CLHAs), a new model of excitable cells that efficiently and accurately captures action-potential morphology and other typical excitable-cell characteristics such as refractoriness and restitution, is introduced. Hybrid automata combine discrete transition graphs with continuous dynamics and emerge in a natural way during the (piecewise) approximation process of any no... View full abstract»

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  • Design and mathematical modelling of a synthetic symbiotic ecosystem

    Publication Year: 2008 , Page(s): 33 - 38
    Save to Project icon | Click to expandAbstract | PDF file iconPDF (149 KB)  

    Artificial microbial ecosystems have been increasingly used to understand principles of ecology. These systems offer unique capabilities to mimic a variety of ecological interactions that otherwise would be difficult to study experimentally in a reasonable period of time. However, the elucidation of the genetic bases for these interactions remains a daunting challenge. To address this issue, we ha... View full abstract»

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  • Structural robustness of biochemical network models-with application to the oscillatory metabolism of activated neutrophils

    Publication Year: 2008 , Page(s): 39 - 47
    Cited by:  Papers (3)
    Save to Project icon | Click to expandAbstract | PDF file iconPDF (441 KB)  

    Sensitivity of biochemical network models to uncertainties in the model structure, with a focus on autonomously oscillating systems, is addressed. Structural robustness, as defined here, concerns the sensitivity of the model predictions with respect to changes in the specific interactions between the network components and encompass, for instance, uncertain kinetic models, neglected intermediate r... View full abstract»

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  • Phase coupling in the cardiorespiratory interaction

    Publication Year: 2008 , Page(s): 48 - 54
    Save to Project icon | Click to expandAbstract | PDF file iconPDF (301 KB)  

    Markovian analysis is applied to derive nonlinear stochastic equations for the reconstruction of heart rate and respiration rate variability data. A model of their `phase` interactions is obtained for the first time, thereby gaining new insights into the strength and direction of the cardiorespiratory phase coupling. The reconstructed model can reproduce synchronisation phenomena between the cardi... View full abstract»

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Aims & Scope

IET Systems Biology covers intra- and inter-cellular dynamics, using systems- and signal-oriented approaches.

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