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IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems

Issue 2 • Feb. 2006

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  • Table of contents

    Publication Year: 2006, Page(s): c1
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  • IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems publication information

    Publication Year: 2006, Page(s): c2
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  • Guest Editorial

    Publication Year: 2006, Page(s):209 - 210
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  • Microfluidics-Based Biochips: Technology Issues, Implementation Platforms, and Design-Automation Challenges

    Publication Year: 2006, Page(s):211 - 223
    Cited by:  Papers (101)  |  Patents (9)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (776 KB) | HTML iconHTML

    Microfluidics-based biochips are soon expected to revolutionize clinical diagnosis, deoxyribonucleic acid (DNA) sequencing, and other laboratory procedures involving molecular biology. In contrast to continuous-flow systems that rely on permanently etched microchannels, micropumps, and microvalves, digital microfluidics offers a scalable system architecture and dynamic reconfigurability; groups of... View full abstract»

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  • Modeling and Simulation of Electrified Droplets and Its Application to Computer-Aided Design of Digital Microfluidics

    Publication Year: 2006, Page(s):224 - 233
    Cited by:  Papers (10)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (736 KB) | HTML iconHTML

    Digital microfluidics is the second-generation lab-on-a-chip architecture based upon micromanipulation of droplets via a programmed external electric field by an individually addressable electrode array. Dielectrophoresis (DEP) and electrowetting-on-dielectric (EWOD) are of dominant operating principles. The microfluidic mechanics of manipulating electrified droplets are complex and not entirely u... View full abstract»

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  • Modeling, Simulation, and Optimization of Electrowetting

    Publication Year: 2006, Page(s):234 - 247
    Cited by:  Papers (34)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (776 KB) | HTML iconHTML

    Electrowetting is an elegant method to realize the motion, dispensing, splitting, and mixing of single droplets in a microfluidic system without the need for any mechanical—and fault-prone—components. By only applying an electric voltage, the interfacial energy of the fluid–solid interface is altered and the contact line of the droplet is changed. However, since the droplet shape... View full abstract»

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  • Algorithms in FastStokes and Its Application to Micromachined Device Simulation

    Publication Year: 2006, Page(s):248 - 257
    Cited by:  Papers (8)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (536 KB) | HTML iconHTML

    For a wide variety of micromachined devices, designers need accurate analysis of fluid drag forces for complicated three-dimensional (3-D) problems. This paper describes FastStokes, a recently developed 3-D fluid analysis program. FastStokes rapidly computes drag forces on complicated structures by solving an integral formulation of the Stokes equation using a precorrected fast Fourier transform (... View full abstract»

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  • Composable Behavioral Models and Schematic-Based Simulation of Electrokinetic Lab-on-a-Chip Systems

    Publication Year: 2006, Page(s):258 - 273
    Cited by:  Papers (12)  |  Patents (1)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (894 KB) | HTML iconHTML

    This paper presents composable behavioral models and a schematic-based simulation methodology to enable top-down design of electrokinetic (EK) lab-on-a-chip (LoC). Complex EK LoCs are shown to be decomposable into a system of elements with simple geometry and specific function. Parameterized and analytical models are developed to describe the electric and biofluidic behavior within each element. E... View full abstract»

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  • FFTSVD: A Fast Multiscale Boundary-Element Method Solver Suitable for Bio-MEMS and Biomolecule Simulation

    Publication Year: 2006, Page(s):274 - 284
    Cited by:  Papers (25)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (536 KB) | HTML iconHTML

    This paper presents a fast boundary-element method (BEM) algorithm that is well suited for solving electrostatics problems that arise in traditional and bio-microelectromechanical systems (bio-MEMS) design. The algorithm, FFTSVD, is Green's-function-independent for low-frequency kernels and efficient for inhomogeneous problems. FFTSVD is a multiscale algorithm that decomposes the problem domain us... View full abstract»

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  • Macromodel Generation for BioMEMS Components Using a Stabilized Balanced Truncation Plus Trajectory Piecewise-Linear Approach

    Publication Year: 2006, Page(s):285 - 293
    Cited by:  Papers (19)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (392 KB) | HTML iconHTML

    In this paper, we present a technique for automatically extracting nonlinear macromodels of biomedical microelectromechanical systems devices from physical simulation. The technique is a modification of the recently developed trajectory piecewise-linear approach, but uses ideas from balanced truncation to produce much lower order and more accurate models. The key result is a perturbation analysis ... View full abstract»

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  • System-Level Simulation of Flow-Induced Dispersion in Lab-on-a-Chip Systems

    Publication Year: 2006, Page(s):294 - 304
    Cited by:  Papers (10)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (456 KB) | HTML iconHTML

    The development of lab-on-a-chip systems has moved from the demonstration of individual components to a complex assembly of components. Due to the increased complexities associated with model setup and computational time requirements, current design approaches using spatial and time-resolved multiphysics modeling, though viable for component-level characterization, become unaffordable for system-l... View full abstract»

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  • Computer-Aided Optimization of DNA Array Design and Manufacturing

    Publication Year: 2006, Page(s):305 - 320
    Cited by:  Papers (2)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (470 KB) | HTML iconHTML

    DNA probe arrays, or DNA chips, have emerged as a core genomic technology that enables cost-effective gene expression monitoring, mutation detection, single nucleotide polymorphism analysis, and other genomic analyses. DNA chips are manufactured through a highly scalable process called very large-scale immobilized polymer synthesis (VLSIPS) that combines photolithographic technologies adapted from... View full abstract»

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  • Synthesis of Multiplexed Biofluidic Microchips

    Publication Year: 2006, Page(s):321 - 333
    Cited by:  Papers (10)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (456 KB) | HTML iconHTML

    Lab-on-a-chip (LoC) devices are a class of microfluidic chip-based systems that show a great deal of promise for complex chemical and biological sensing and analysis applications. An approach for full-custom LoC design, which leverages optimal design techniques and system-on-a-chip (SoC) physical design methods, is being developed. Both physical design of the chip and microfluidic performance are ... View full abstract»

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  • Modeling and Controlling Parallel Tasks in Droplet-Based Microfluidic Systems

    Publication Year: 2006, Page(s):334 - 344
    Cited by:  Papers (65)  |  Patents (3)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (585 KB) | HTML iconHTML

    This paper presents general hardware-independent models and algorithms to automate the operation of droplet-based microfluidic systems. In these systems, discrete liquid volumes of typically less than 1$muhboxl$are transported across a planar array by dielectrophoretic or electrowetting effects for biochemical analysis. Unlike in systems based on continuous flow through channels, valves... View full abstract»

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  • Performance Characterization of a Reconfigurable Planar-Array Digital Microfluidic System

    Publication Year: 2006, Page(s):345 - 357
    Cited by:  Papers (80)  |  Patents (2)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (736 KB) | HTML iconHTML

    This paper describes a computational approach to designing a digital microfluidic system (DMFS) that can be rapidly reconfigured for new biochemical analyses. Such a “lab-on-a-chip” system for biochemical analysis, based on electrowetting or dielectrophoresis, must coordinate the motions of discrete droplets or biological cells using a planar array of electrodes. The authors have earli... View full abstract»

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  • A Pattern-Mining Method for High-Throughput Lab-on-a-Chip Data Analysis

    Publication Year: 2006, Page(s):358 - 377
    Cited by:  Papers (3)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1120 KB) | HTML iconHTML

    Biochips are emerging as a useful tool for high-throughput acquisition of biological data and continue to grow in information quality and in discovering new applications. Recent advances include CMOS-based integrated biosensor arrays for deoxyribonucleic acid (DNA) expression analysis (Hassibi and Lee, 2005), (Schienle , 2004), and active research is ongoing for the miniaturization and integration... View full abstract»

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  • Microfluidic Injector Models Based on Artificial Neural Networks

    Publication Year: 2006, Page(s):378 - 385
    Cited by:  Papers (6)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (554 KB) | HTML iconHTML

    Lab-on-a-chip (LoC) systems can be functionally decomposed into their basic operating devices. Common devices are mixers, reactors, injectors, and separators. In this paper, the injector device is modeled using artificial neural networks (NNs) trained with finite element simulations of the underlying mass transport partial differential equations (PDEs). This technique is used to map the injector b... View full abstract»

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  • 49th IEEE International Midwest Symposium on Circuits and Systems (MWSCAS 2006)

    Publication Year: 2006, Page(s): 386
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  • International Symposium on Low Power Electronics and Design (ISLPED'06)

    Publication Year: 2006, Page(s): 387
    Request permission for commercial reuse | PDF file iconPDF (675 KB)
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  • 2006 IEEE International Symposium on Circuits and Systems (ISCAS 2006)

    Publication Year: 2006, Page(s): 388
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  • IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems society information

    Publication Year: 2006, Page(s): c3
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  • IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems Information for authors

    Publication Year: 2006, Page(s): c4
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Aims & Scope

The purpose of this Transactions is to publish papers of interest to individuals in the area of computer-aided design of integrated circuits and systems composed of analog, digital, mixed-signal, optical, or microwave components.

Full Aims & Scope

Meet Our Editors

Editor-in-Chief

VIJAYKRISHNAN NARAYANAN
Pennsylvania State University
Dept. of Computer Science. and Engineering
354D IST Building
University Park, PA 16802, USA
vijay@cse.psu.edu