By Topic

IEE Proceedings - Systems Biology

Issue 1 • Date 14 March 2005

Filter Results

Displaying Results 1 - 6 of 6
  • Systems Biology: Will it work?

    Publication Year: 2005, Page(s):1 - 4
    IEEE is not the copyright holder of this material | Click to expandAbstract | PDF file iconPDF (622 KB)

    Reports on meeting of Biochemical Society UK from 12-14 Jan. 2005. A general description of systems biology is that it is the use of mathematics and modelling to answer two questions (1) how do cell components function and (2) how do cells interact to bring about tissue/organ function. View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • Combinatorial complexity and dynamical restriction of network flows in signal transduction

    Publication Year: 2005, Page(s):5 - 15
    Cited by:  Papers (1)
    IEEE is not the copyright holder of this material | Click to expandAbstract | PDF file iconPDF (1198 KB)

    The activities and interactions of proteins that govern the cellular response to a signal generate a multitude of protein phosphorylation states and heterogeneous protein complexes. Here, using a computational model that accounts for 307 molecular species implied by specified interactions of four proteins involved in signalling by the immunoreceptor FcεRI, we determine the relative importance... View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • Model identification of signal transduction networks from data using a state regulator problem

    Publication Year: 2005, Page(s):17 - 30
    Cited by:  Papers (6)
    IEEE is not the copyright holder of this material | Click to expandAbstract | PDF file iconPDF (631 KB)

    Advances in molecular biology provide an opportunity to develop detailed models of biological processes that can be used to obtain an integrated understanding of the system. However, development of useful models from the available knowledge of the system and experimental observations still remains a daunting task. In this work, a model identification strategy for complex biological networks is pro... View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • Precision of intracellular calcium spike timing in primary rat hepatocytes

    Publication Year: 2005, Page(s):31 - 34
    IEEE is not the copyright holder of this material | Click to expandAbstract | PDF file iconPDF (639 KB)

    Extracellular stimuli are often encoded in the frequency, amplitude and duration of spikes in the intracellular concentration of calcium ([Ca2+]i). However, the timing of individual [Ca2+]i-spikes in relation to the dynamics of an extracellular stimulus is still an open question. To address this question, we use a systems biology approach combining exper... View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • Analysing the robustness of cellular rhythms

    Publication Year: 2005, Page(s):35 - 41
    IEEE is not the copyright holder of this material | Click to expandAbstract | PDF file iconPDF (545 KB)

    Autonomous oscillations at the cellular level are important for various timing and signalling functions. The rhythms depend on environmental influences in a specific manner. In particular, the period of some rhythms has been shown to be very robust to certain environmental factors whereas other rhythms show a high sensitivity towards these factors. It is discussed that the robustness of the system... View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • STAT module can function as a biphasic amplitude filter

    Publication Year: 2005, Page(s):43 - 52
    IEEE is not the copyright holder of this material | Click to expandAbstract | PDF file iconPDF (955 KB)

    Signal transducer and actuator of transcription (STATs) are a family of transcription factors activated by various cytokines, growth factors and hormones. They are important mediators of immune responses and growth and differentiation of various cell types. The STAT signalling system represents a defined functional module with a pattern of signalling that is conserved from flies to mammals. In ord... View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.