Proceedings of the IEEE

Issue 4 • April 2005

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Displaying Results 1 - 21 of 21
  • [Front cover]

    Publication Year: 2005, Page(s): c1
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  • IEEE Member Digital Library [advertisement]

    Publication Year: 2005, Page(s): c2
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  • Table of contents

    Publication Year: 2005, Page(s): 721
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  • Proceedings of the IEEE publication information

    Publication Year: 2005, Page(s): 722
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  • Special Issue on Molecular Imaging: Emerging Technology and Biomedical Applications

    Publication Year: 2005, Page(s):723 - 725
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  • Intelligent Biohybrid Materials for Therapeutic and Imaging Agent Delivery

    Publication Year: 2005, Page(s):726 - 736
    Cited by:  Papers (23)  |  Patents (12)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (491 KB) | HTML iconHTML

    Many molecular imaging techniques rely on tracer methods to visualize specific physiological processes in cells, animals, and humans. A new family of "smart" delivery systems for biomolecules has opened new opportunities for the molecular imaging field. One class of polymeric carriers reversibly become membrane destabilizing in response to sharp pH changes and were designed for delivering proteins... View full abstract»

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  • Gene Array Technologies in Biological Investigations

    Publication Year: 2005, Page(s):737 - 749
    Cited by:  Papers (2)  |  Patents (2)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (579 KB) | HTML iconHTML

    Microarray technology is a high-throughput platform for the comprehensive analysis of gene expression on a whole genome scale. Most approaches use a solid phase surface to geographically fix specific gene probes and quantification is based on radiometric, fluorometric, or electrochemical detection of hybridized biomolecules such as RNA, DNA, or protein. The technique produces two-dimensional "imag... View full abstract»

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  • Using in Vivo Bioluminescence Imaging to Shed Light on Cancer Biology

    Publication Year: 2005, Page(s):750 - 762
    Cited by:  Papers (21)  |  Patents (2)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (628 KB) | HTML iconHTML

    Luciferases are light-emitting enzymes that have been used as reporters of biological function for several decades, and have more recently been used as reporters for the study of biological processes in living animals. Although these enzymes appear to have evolved independently in different species, they are all oxygenases that require energy, a chemical substrate, and oxygen. The technologies of ... View full abstract»

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  • Development of a Small-Animal PET System

    Publication Year: 2005, Page(s):763 - 770
    Cited by:  Papers (6)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1496 KB) | HTML iconHTML

    Developments in small-animal positron emission tomography (PET) technology aim at reaching spatial resolution in the submillimeter range and increasing the system sensitivity. Various detector schemes have been implemented in complete tomographic systems for in vivo animal imaging. These include small scintillation crystals read out by multichannel-photomultiplier tubes with optical fibers to guid... View full abstract»

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  • Multimodality Radionuclide, Fluorescence, and Bioluminescence Small-Animal Imaging

    Publication Year: 2005, Page(s):771 - 783
    Cited by:  Papers (23)  |  Patents (1)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (504 KB) | HTML iconHTML

    The imaging of molecular events in the complex physiological interplay between organelles, cells, tissues, and organs in the whole organism is now more practical through the use of small-animal imaging technologies. Radionuclide based molecular imaging using single photon emission computed tomography (SPECT) and positron emission tomography (PET) scanners have been used for imaging intracellular e... View full abstract»

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  • Molecular Imaging of Cancer: Applications of Magnetic Resonance Methods

    Publication Year: 2005, Page(s):784 - 799
    Cited by:  Papers (11)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1079 KB) | HTML iconHTML

    Cancer is a complex disease exhibiting a host of phenotypic diversities. Noninvasive multinuclear magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) provide an array of capabilities to characterize and understand several of the vascular, metabolic, and physiological characteristics unique to cancer. The availability of targeted contrast agents has widened the scope of MR techniques ... View full abstract»

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  • Molecular MR Imaging Probes

    Publication Year: 2005, Page(s):800 - 808
    Cited by:  Papers (3)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (637 KB) | HTML iconHTML

    Magnetic resonance imaging (MRI) has been successfully applied to many of the applications of molecular imaging. This review discusses by example some of the advances in areas such as multimodality MR-optical agents, receptor imaging, apoptosis imaging, angiogenesis imaging, noninvasive cell tracking, and imaging of MR marker genes. View full abstract»

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  • Molecular and Cellular Imaging with Targeted Contrast Ultrasound

    Publication Year: 2005, Page(s):809 - 818
    Cited by:  Papers (19)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (550 KB) | HTML iconHTML

    Molecular imaging is an expanding field that involves the noninvasive detection of cellular and molecular mediators of disease using a range of imaging modalities. Molecular imaging using contrast-enhanced ultrasound relies on the detection of novel site-targeted ultrasound contrast agents. Gas-filled encapsulated microbubbles provide a sensitive and high-resolution ultrasound contrast agent, and ... View full abstract»

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  • From Genomics to Clinical Molecular Imaging

    Publication Year: 2005, Page(s):819 - 828
    Cited by:  Papers (12)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (696 KB) | HTML iconHTML

    Molecular imaging, as applied to clinical practice today, is in its early stages. Encouraging advances achieved in clinical positron emission tomography (PET) and small-animal imaging indicate that this technique is evolving into an indispensable diagnostic tool. When employed with complementary morphological imaging procedures, molecular imaging results in substantial diagnostic capability. It wi... View full abstract»

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  • Photonics Technology for Molecular Imaging

    Publication Year: 2005, Page(s):829 - 843
    Cited by:  Papers (3)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (3299 KB) | HTML iconHTML

    Recent progress in photonics technologies contributing to the advancements of molecular imaging are reviewed from an industrial point of view. Many imaging modalities have been developed for molecular imaging, and many of these methods rely on the detection of "photons" as a basis for image formation. These include positron emission tomography (PET), near-infrared spectroscopy (NIRS), and fluoresc... View full abstract»

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  • Radar 101: Celebrating 101 Years of Development

    Publication Year: 2005, Page(s):844 - 846
    Cited by:  Papers (1)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (768 KB) | HTML iconHTML

    Most inventions that are relevant to practical applications in our society are recognized from the start, with a few exceptions. The invention and development of radar was one of the notable exceptions, which is all the more remarkable considering the newer and more widespread applications of this technology in many areas, including as an anti-collision device in the automobile. And yet, incredibl... View full abstract»

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  • Future Special Issues/Special Sections of the IEEE Proceedings

    Publication Year: 2005, Page(s):847 - 849
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  • Explore IEL IEEE's most comprehensive resource [advertisement]

    Publication Year: 2005, Page(s): 850
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  • IEEE copyright form

    Publication Year: 2005, Page(s):851 - 852
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  • Put your technology leadership in writing

    Publication Year: 2005, Page(s): c3
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  • Proceedings of the IEEE check out our May issue

    Publication Year: 2005, Page(s): c4
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Editor-in-Chief
H. Joel Trussell
North Carolina State University