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IEEE/ACM Transactions on Computational Biology and Bioinformatics

Issue 3 • Date July-Sept. 2004

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Displaying Results 1 - 11 of 11
  • [Front cover]

    Publication Year: 2004, Page(s): c1
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  • [Inside front cover]

    Publication Year: 2004, Page(s): c2
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  • Introduction of new Associate Editors

    Publication Year: 2004, Page(s): 97
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  • A stochastic downhill search algorithm for estimating the local false discovery rate

    Publication Year: 2004, Page(s):98 - 108
    Cited by:  Papers (13)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (952 KB) | HTML iconHTML

    Screening for differential gene expression in microarray studies leads to difficult large-scale multiple testing problems. The local false discovery rate is a statistical concept for quantifying uncertainty in multiple testing. We introduce a novel estimator for the local false discovery rate that is based on an algorithm which splits all genes into two groups, representing induced and noninduced ... View full abstract»

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  • Constructing splits graphs

    Publication Year: 2004, Page(s):109 - 115
    Cited by:  Papers (40)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (463 KB) | HTML iconHTML

    Phylogenetic trees correspond one-to-one to compatible systems of splits and so splits play an important role in theoretical and computational aspects of phylogeny. Whereas any tree reconstruction method can be thought of as producing a compatible system of splits, an increasing number of phylogenetic algorithms are available that compute split systems that are not necessarily compatible and, thus... View full abstract»

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  • Improved gapped alignment in BLAST

    Publication Year: 2004, Page(s):116 - 129
    Cited by:  Papers (27)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1137 KB) | HTML iconHTML

    Homology search is a key tool for understanding the role, structure, and biochemical function of genomic sequences. The most popular technique for rapid homology search is BLAST, which has been in widespread use within universities, research centers, and commercial enterprises since the early 1990s. We propose a new step in the BLAST algorithm to reduce the computational cost of searching with neg... View full abstract»

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  • Unidentifiable divergence times in rates-across-sites models

    Publication Year: 2004, Page(s):130 - 134
    Cited by:  Papers (5)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (178 KB) | HTML iconHTML

    The rates-across-sites assumption in phylogenetic inference posits that the rate matrix governing the Markovian evolution of a character on an edge of the putative phylogenetic tree is the product of a character-specific scale factor and a rate matrix that is particular to that edge. Thus, evolution follows basically the same process for all characters, except that it occurs faster for some charac... View full abstract»

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  • [Advertisement]

    Publication Year: 2004, Page(s): 135
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  • [Advertisement]

    Publication Year: 2004, Page(s): 136
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  • IEEE/ACM TCBB: Information for authors

    Publication Year: 2004, Page(s): c3
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  • [Back cover]

    Publication Year: 2004, Page(s): c4
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Aims & Scope

This bimonthly publishes archival research results related to the algorithmic, mathematical, statistical, and computational methods that are central in bioinformatics and computational biology.

Full Aims & Scope

Meet Our Editors

Editor-in-Chief
Ying Xu
University of Georgia
xyn@bmb.uga.edu

Associate Editor-in-Chief
Dong Xu
University of Missouri
xudong@missouri.edu