By Topic

Nanobiotechnology, IEE Proceedings -

Issue 1 • Date 18 June 2003

Filter Results

Displaying Results 1 - 7 of 7
  • Biomolecular applications of carbon nanotubes

    Page(s): 3 - 8
    Save to Project icon | Click to expandQuick Abstract | PDF file iconPDF (606 KB)  

    Carbon nanotubes are a significant addition to the emerging field of nanotube biotechnology. The biocompatibility, high structural integrity, and unique electronic and mechanical properties of carbon nanotubes complement or surpass those of self-assembled lipid nanotubes, peptide nanotubes, and template-synthesised nanotubes (metals, polymers, semiconductors, and carbons). Carbon nanotubes are candidates for a range of biomolecular applications that is likely to widen considerably in the future. View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • Computer-controlled piezoactuator for cell manipulation

    Page(s): 15 - 20
    Save to Project icon | Click to expandQuick Abstract | PDF file iconPDF (466 KB)  

    The development of a computer-controlled piezomanipulation system is presented for biomedical applications involving cells manipulation. An application of the developed system to intracytoplasmic sperm injection (ICSI) is presented. The hardware setup and the control strategies are described in full detail to illustrate the advantages of this approach compared to manual injection methods. The system developed offers the automated and efficient execution of the ICSI process, thus achieving an improved success rate in terms of the end objectives of the process. View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • Theoretical study of stability problems for transport in a deformable microfabricated channel

    Page(s): 21 - 23
    Save to Project icon | Click to expandQuick Abstract | PDF file iconPDF (320 KB)  

    We investigate the stability problem related to the basic flows induced by peristaltic transport within the bounded deformable walls which are common in micro- and/or nanobiotechnological applications. The neutral stability boundary is obtained by solving the relevant Orr-Sommerfeld equation via a verified preconditioned complex-matrix solver. The critical Reynolds number (when the wall is deformable) is 2886.5 which is much less than the conventional rigid-wall case (∼5772, obtained by Orszag based on the spectral method). View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • Implementation of a redox microarray: an experimental model for future nanoscale biomolecular computing using integrated circuits

    Page(s): 9 - 14
    Save to Project icon | Click to expandQuick Abstract | PDF file iconPDF (444 KB)  

    The possibility of constructing high-density parallel computing architectures using molecular electronics technology is explored. By employing molecular computing devices, new circuit/system integration could be realised. To clarify the proposed concept, an experimental model of a redox microarray is presented. A first experimental system for a redox microarray consists of a two-dimensional array of platinum microelectrodes to catalyse reversible reactions of redox-active molecules. Experimental results of active wave propagation in the redox microarray are presented to demonstrate the potential of molecular computing devices for creating artificially programmable reaction-diffusion dynamics for specific target applications. View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • Preliminary electrochemical characterisation of cytochrome P4501A2-clozapine interaction

    Page(s): 31 - 34
    Save to Project icon | Click to expandQuick Abstract | PDF file iconPDF (395 KB)  

    Cytochromes P450 are a large superfamily of heme-thiolate enzymes involved in the metabolism of many different organic substrates such as drugs, fatty acids and toxic compounds. The aim of this work is to analyse the binding between the cytochrome P4501A2, in solution and in gel-matrix, and its substrate (clozapine), utilising voltammetric tests. The interaction measurements were carried out using two different screen printed electrodes (rhodium-graphite and graphite-riboflavin), and the results were compared. It was demonstrated that it is possible to realise a biosensor prototype to detect the presence of clozapine indirectly by chronoamperometry. View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • Editorial

    Page(s): 1 - 2
    Save to Project icon | Click to expandQuick Abstract | PDF file iconPDF (252 KB)  

    First Page of the Article
    View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.
  • Planar silicon nitride waveguides for biosensing

    Page(s): 25 - 30
    Save to Project icon | Click to expandQuick Abstract | PDF file iconPDF (475 KB)  

    The principles of attenuation of the light intensity due to multiple reflections are realised in a planar silicon oxide (SiO2)/silicon nitride (Si3N4) waveguiding structure for the purpose of developing optical biosensors with improved sensitivity. The analysis of the experimental data shows that the large difference in refractive indices of core and cladding layers gives rise to an increase in sensitivity by a factor of 3 over previously reported structures. Composite polyelectrolyte self-assembled thin films containing cyclo-tetra-chromotropylene as an indicator and enzymes glucose oxidase or urease were employed in the superstrate as a sensing membrane. Individual enzyme reactions as well as their inhibition by pesticides were studied by monitoring the intensity of light output from the planar waveguide. The results were compatible with those obtained by conventional ultraviolet-visible absorption spectroscopy. The instrument detection limit for Imidacloprid pesticide was found to be as low as 10 ppb in concentration. View full abstract»

    Full text access may be available. Click article title to sign in or learn about subscription options.