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Computing in Science & Engineering

Issue 3 • Date May-June 1999

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Displaying Results 1 - 14 of 14
  • Computational biology

    Publication Year: 1999 , Page(s): 16 - 17
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  • A direct approach to solving optimal control problems

    Publication Year: 1999 , Page(s): 73 - 75
    Cited by:  Papers (7)
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    Historically, researchers have solved optimal control problems using the calculus of variations-an approach called the indirect method. This technique led to the solution of a multipoint boundary value problem. Unfortunately, in practice, the indirect method is often insufficient. To eliminate the indirect method's deficiencies, an approach called direct transcription has been developed. For most problems, this method is robust, needs minimal user interaction to define the problem, does not require any additional analytic derivations, and treats path constraints automatically. View full abstract»

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  • Marketing eau de Skunqoil: Only on the internet

    Publication Year: 1999 , Page(s): 88 - 89
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  • Computational problems in cell biology

    Publication Year: 1999 , Page(s): 26 - 32
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    Obtaining a predictive understanding of cell behavior will require new computational methods, as well as adaptations of traditional techniques of optimization and system analysis. The authors discuss the challenges cell biologists face in their effort to control information transfer in cells View full abstract»

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  • The computational challenge of linkage analysis: what causes diseases?

    Publication Year: 1999 , Page(s): 18 - 25
    Cited by:  Papers (1)
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    Finding the genetic causes of disease is a challenging problem for biologists and mathematicians alike. This article describes the difficulties of the problem, two general algorithmic approaches to solving it, and areas of current research where the problem has not yet been adequately solved View full abstract»

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  • Creativity is key to drug R&D

    Publication Year: 1999 , Page(s): 6 - 9
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    In a world where time to market is money, the pharmaceutical industry faces special challenges. To improve their candidate drugs' odds and decrease development time and costs, pharmaceutical companies have started to form numerous alliances with public and private institutions and launch major research and development initiatives. The author considers how scientific and computational advances have created unprecedented opportunities for innovation View full abstract»

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  • Whole-genome DNA sequencing

    Publication Year: 1999 , Page(s): 33 - 43
    Cited by:  Papers (12)  |  Patents (11)
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    Computation is integrally and powerfully involved with the DNA sequencing technology that promises to reveal the complete human DNA sequence in the next several years. After introducing the latest DNA sequencing methods, this article describes three current approaches for completing the sequencing View full abstract»

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  • AceDB: a genome database management system

    Publication Year: 1999 , Page(s): 44 - 52
    Cited by:  Papers (3)
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    The Human Genome Project has spawned many databases using custom software or with conventional data management systems. Surprisingly, amidst this wealth of genome database systems, few ready-made systems are available to a group that wishes to set up its own genome database or even to an individual interested in experimenting with them to learn more about bioinformatics. Many genome database systems are unavailable for distribution or are so specialized to their task that it is impractical to adapt them for use at another site. Jean Thierry-Mieg and Richard Durbin disproved this generalization by designing AceDB-an object-oriented database system-from the ground up to represent genomes and other complex biological data. Application programmers can use its APIs to fetch, examine, and modify data maintained in a variety of AceDB genome databases View full abstract»

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  • Scientific computation and functional programming

    Publication Year: 1999 , Page(s): 64 - 72
    Cited by:  Papers (4)
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    Modern functional programming languages and lazy functional techniques are useful for describing and implementing abstract mathematical objects in quantum mechanics. Scientists can use them both for pedagogical purposes and for real, not too computationally intensive, but conceptually and algorithmically difficult applications. This article shows how to perform simple abstract computations on state vectors and discusses the construction of lazy algorithms that enormously simplify manipulation of potentially infinite data structures or iterative processes. Lazy functional techniques can often replace the use of symbolic computer algebra packages, while also offering an interesting algorithmic complement to the manipulation of mathematical data. These techniques are more efficient than blindly used symbolic algebra and are easy to integrate with the numerical code View full abstract»

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  • Spheroidal wave functions

    Publication Year: 1999 , Page(s): 84 - 87
    Cited by:  Papers (3)
    Save to Project icon | Request Permissions | Click to expandQuick Abstract | PDF file iconPDF (320 KB)  

    Spheroidal wave functions occur in many scientific and engineering contexts, from atomic nuclei to the cosmos-scattering by nonspherical nuclei, wave functions of diatomic molecules, analysis of band-limited random noise, orthogonal frequency division multiplexing, and anisotropy of the cosmic microwave background radiation. Therefore, visualizing these functions and computing them reliably can be useful and interesting View full abstract»

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  • How simulations clarify complex material phase transitions

    Publication Year: 1999 , Page(s): 10 - 12
    Cited by:  Papers (1)
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    Since Monte Carlo and molecular dynamics (MD) simulations were invented as a tool less than 50 years ago to study thermal properties of condensed matter, two general problems have come into focus: fluid properties and phase transitions. The paper considers how atomistic simulations can clarify phase transitions of simple systems, formed from atoms of a pure substance or from small molecules, in quantitative details View full abstract»

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  • A critical look at quality in large-scale simulations

    Publication Year: 1999 , Page(s): 53 - 63
    Cited by:  Papers (6)
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    There is a disconnect between ASCI science and management. The author proposes an alternative paradigm. Simulation quality depends on the quality of insights gained, but software engineering is not the discipline to develop those insights. The author also proposes a definition for validation and differentiates it from current internal quality and verification approaches View full abstract»

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  • Parametric resonance

    Publication Year: 1999 , Page(s): 76 - 83
    Cited by:  Papers (2)
    Save to Project icon | Request Permissions | Click to expandQuick Abstract | PDF file iconPDF (564 KB)  

    Computer simulation experiments are especially good tools for helping students understand basic principles of physics. In this a, I have developed a package of simulation programs called Physics of Oscillations. One of its programs is suited for examining the phenomenon of paramagnetic resonance in a linear system. The program simulates the parametric excitation of the rotary oscillations of a mechanical torsion-spring pendulum whose moment of inertia is subject to periodic variations. I discuss the conditions and characteristics of parametric resonance, including paramagnetic regeneration. Instructors and their students can also use the Physics of Oscillations package to explore other problems, such as ranges of frequencies within which parametric excitation is possible and stationary oscillations on the boundaries of these ranges. The simulation experiments complement the analytical study of the subject in a manner that is mutually reinforcing View full abstract»

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  • Educational software and the Sisyphus effect

    Publication Year: 1999 , Page(s): 13 - 15
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    The author discusses the acceptance and widespread use of educational software for physics teaching. He considers software authoring, the Internet and the JiTT paradigm View full abstract»

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Aims & Scope

Computing in Science & Engineering presents scientific and computational contributions in a clear and accessible format.

Full Aims & Scope

Meet Our Editors

Editor-in-Chief
George K. Thiruvathukal
Loyola University