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2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology

12-15 May 2005

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  • 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology (IEEE Cat. No. 05EX937)

    Publication Year: 2005
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  • [Title page]

    Publication Year: 2005, Page(s): i
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  • Copyright page

    Publication Year: 2005, Page(s): ii
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  • Program messages

    Publication Year: 2005, Page(s): iii
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  • Editor's notes

    Publication Year: 2005, Page(s): iv
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  • Schedule/agenda

    Publication Year: 2005, Page(s): v
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  • Schedule/agenda

    Publication Year: 2005, Page(s): vi
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  • Schedule/agenda

    Publication Year: 2005, Page(s):vii - ix
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  • Conference committee

    Publication Year: 2005, Page(s):x - xi
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  • Keynote address

    Publication Year: 2005, Page(s):xiii - xv
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (2045 KB) | HTML iconHTML

    Provides an abstract for each of the keynote presentations and a brief professional biography of each presenter. The complete presentations were not made available for publication as part of the conference proceedings. View full abstract»

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  • Other messages

    Publication Year: 2005, Page(s):xvi - xvii
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  • Indexes

    Publication Year: 2005, Page(s):xxi - xxxii
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  • Table of contents

    Publication Year: 2005, Page(s):xxxiii - xliv
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  • Nanoshuttles driven by biological motors

    Publication Year: 2005
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (128 KB) | HTML iconHTML

    Biological motors are used by cells to actively transport ions and molecules against concentrations thereby establishing non-equilibrium conditions that are essential for many life processes. Borrowing from nature, we are developing insights into how to engineer nanoscale transport systems based on the biological motors kinesin and microtubules. Molecular shuttle systems may enhance the detection ... View full abstract»

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  • Opportunities for microtechnology in ion channel research

    Publication Year: 2005
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (160 KB) | HTML iconHTML

    Ion channels are proteins in cell membranes that act as molecular switches and transducers, controlling currents of ions in response to electrical, chemical or mechanical stimuli. The two major problems in ion channel research for which new microdevices are needed are described. The first is the need for better "patch clamp" recordings of ion channel currents in living cells. The second problem is... View full abstract»

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  • Insulating dielectrophoresis for the continuous separation and concentration of Bacillus subtilis

    Publication Year: 2005, Page(s):3 - 4
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (2144 KB) | HTML iconHTML

    This paper presents a novel microdevice for the dielectrophoretic manipulation of particles and cells for sample preparation and analysis. A two level isotropic etch of a glass substrate was used to create insulating ridges in micron sized channels. These ridges created a non-uniform field when a direct current field was applied across the channel and the dielectrophoretic force that resulted from... View full abstract»

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  • Multi-DNA extraction chip based on an aluminum oxide membrane integrated into a PDMS microfluidic structure

    Publication Year: 2005, Page(s):5 - 7
    Cited by:  Papers (1)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1744 KB) | HTML iconHTML

    A novel microfluidic DNA extraction system was designed and fabricated using an AOM (aluminum oxide membrane) capture surface sandwiched between PDMS microfluidic channels in a parallel format. The completed system was tested with Lambda DNA mixed with the fluorescence dye SYBR Green I. Following extraction, the surface of AOM was examined with fluorescence microscopy while still embedded in the m... View full abstract»

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  • Continuous plasma separation from whole blood using microchannel geometry

    Publication Year: 2005, Page(s):8 - 9
    Cited by:  Papers (1)  |  Patents (6)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1912 KB) | HTML iconHTML

    Plasma separation from whole blood using microfluidics was investigated. We suggested modified channel geometry called "corner-edge" to enhance plasma skimming effect at branching channel. To evaluate separation efficiency, microfluidic chip was fabricated with silicone elastomer and glass. The efficiency of separation was above 99% comparing with whole blood hematocrit. This microfluidic unit cou... View full abstract»

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  • Improving DNA microarray hybridization with a pulsed source-sink mixing device

    Publication Year: 2005, Page(s):10 - 12
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1552 KB) | HTML iconHTML

    A fundamental study of fluid mixing is used to guide the design of a hybridization chamber for DNA microarray analysis. The focus is on a system consisting of a simple arrangement of flow sources and sinks that efficiently delivers targets across a conventional glass slide array using a series of flow pulses. A quantification of chaotic advection in a reduced-order flow model suggests that optimal... View full abstract»

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  • Microfabricated fluorescence-activated cell sorter with hydrodynamic flow manipulation

    Publication Year: 2005, Page(s):13 - 14
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (2120 KB) | HTML iconHTML

    Presented is a novel flow manipulation and particle detection method for microfabricated fluorescence-activated cell sorter (μFACS). With hydrodynamic flow manipulation, our system guarantees fast and robust operation while sorting fluorescent particles. Moreover by detecting with synchronized imaging, we also developed an on-line calibration technique for accurate timing between detection and ... View full abstract»

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  • Dual capillary electrophoresis devices with electrochemical detection on a single platform

    Publication Year: 2005, Page(s):15 - 17
    Cited by:  Patents (1)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (2040 KB) | HTML iconHTML

    The purpose of this paper is to demonstrate the feasibility of developing a single lab-on-a-chip (LOC) platform capable of performing dual, simultaneous separation and detection of multiple analytes. Computational modeling was performed to determine optimum device geometry and performance. The soda-lime glass-based device was fabricated using traditional microtechnology processes, including UV pho... View full abstract»

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  • Lab-on-a-chip systems with three dimensional microelectrodes

    Publication Year: 2005, Page(s):18 - 21
    Cited by:  Papers (1)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (2400 KB) | HTML iconHTML

    This paper reports on the development and testing of a self-contained portable electrochemical (EC) detection platform capable of monitoring heavy metals (Pb, Cu etc.). Towards this end, a lab-on-a-chip (LOC) device was fabricated by etching a microchannel system into a soda lime glass substrate and incorporating photo-lithographically patterned radial gold microelectrodes at the end of the design... View full abstract»

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  • Open environment micro device for integration of patch clamp instrumentation with targeted microfluidic chemical delivery

    Publication Year: 2005, Page(s):22 - 25
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (3896 KB) | HTML iconHTML

    We describe a technique for the fabrication and use of a microfluidic flow device that has portions that are open to the external environment. Matching inlet and outlet flow rates in the device forms virtual walls through surface tension at the liquid-air interface. Traditional instrumentation, such as the patch-clamp pipette, can be introduced into the flow stream through the surface-tension wall... View full abstract»

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  • Influence of oxygen microenvironment on microfluidic glucose sensor performance

    Publication Year: 2005, Page(s):26 - 27
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (1040 KB) | HTML iconHTML

    We propose a novel method to overcome significant problems of baseline drift and sensitivity degradation in amperometric biosensors based on oxidase enzyme reactions. A novel glucose microsensor with a built-in electrochemical oxygen manipulation microsystem is introduced to demonstrate three novel functionalities; one-point in situ self-calibration (zero-point), broadening of dynamic range and in... View full abstract»

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  • Automated multiplexed multidensity microfluidic (M3) cell sensing based on electrical gain measurements

    Publication Year: 2005, Page(s):28 - 30
    Cited by:  Papers (1)
    Request permission for commercial reuse | Click to expandAbstract | PDF file iconPDF (2472 KB) | HTML iconHTML

    We present the preparation of multi-density cells automated in a microfluidic channel and then sensed with multiplexed surface microelectrode arrays at the bottom of the channel. Decreasing concentrations of cells are prepared by mixing decreasing volumes of cells with increasing volumes of cell culture media. The different cell concentrations are separated by oil blocks. The fluids are driven int... View full abstract»

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