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Optical sensing of biomolecules using microring resonators

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This paper appears in:
Selected Topics in Quantum Electronics, IEEE Journal of
Date of Publication: Jan.-Feb. 2006
Author(s): Yalcin, A.
Boston Univ., MA, USA
Popat, K.C. ;  Aldridge, J.C. ;  Desai, T.A. ;  Hryniewicz, J. ;  Chbouki, N. ;  Little, B.E. ;  Oliver King ;  Van, V. ;  Sai Chu ;  Gill, D. ;  Anthes-Washburn, M. ;  Unlu, M.S. ;  Goldberg, B.B.
Volume: 12 , Issue: 1
Page(s): 148 - 155
Product Type: Journals & Magazines

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Abstract

A biosensor application of vertically coupled glass microring resonators with Q∼12 000 is introduced. Using balanced photodetection, very high signal to noise ratios, and thus high sensitivity to refractive index changes (limit of detection of 1.8×10-5 refractive index units), are achieved. Ellipsometry and X-ray photoelectron spectroscopy results indicate successful modification of biosensor surfaces. Experimental data obtained separately for a bulk change of refractive index of the medium and for avidin-biotin binding on the ring surface are reported. Excellent repeatability and close-to-complete surface regeneration after binding are experimentally demonstrated.

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