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High-Throughput Label-Free Detection Using a Gold Nanoslit Array With 2-D Spectral Images and Spectral Integration Methods

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5 Author(s)
Kuang-Li Lee ; Research Center for Applied Sciences , Academia Sinica, Taipei, Taiwan ; Jui-Ting Tsai ; Min-Jian Chih ; Yeong-Der Yao
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We fabricated gold nanoslit arrays and experimentally compared the sensing capabilities using the single-polarization and multipolarization spectral integration methods. The signal-to-noise ratio and refractive index detection limit using the multipolarization method were increased to three times larger than the simple integration method. Combining 2-D spectral images and the spectral integration method, we demonstrated real time and multiple detections of 30-nm-gold nanoparticles. The detection limit of the system is down to 0.147 particles/μm2.

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IEEE Journal of Selected Topics in Quantum Electronics  (Volume:19 ,  Issue: 3 )