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We investigate the optimal placement of transmit antennas in distributed antenna systems. Our optimization framework imposes no constraints on the location of the antennas. Based on stochastic approximation theory, we adopt a formulation that is suitable for node placement optimization in various wireless network scenarios. We show that optimal placement of antennas inside the coverage region can significantly improve the power efficiency of wireless networks. We obtain the optimal placement topologies for different numbers of antennas and illustrate that the circular deployment is not optimum in general. Finally, we show via simulations that the optimal placement solution does not depend on the underlying shadowing model.