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The cell-based structure, which makes up the majority of biological organisms offers the ability to grow with fault-tolerance abilities and self-repair. By adapting these mechanisms and capabilities from nature, scientific approaches have helped researches understand related phenomena and associated with principles to engine complex novel digital systems and improve their capability. Founded by these observations, the paper is focused on computer-aided modeling, simulation and experimental research of embryonic systems fault-tolerance and selfhealing abilities, with the purpose to implement VLSI hardware structures which are able to imitate cells or artificial organism operation mode, with similar robustness properties like their biological equivalents from nature. The presented theoretical and simulation approaches were tested on a laboratory prototype embryonic system (embryonic machine), built with major purpose to implement self-healing properties of living organisms.