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Congress authorized NASA's Prometheus Project in February 2003, with the first Prometheus mission slated to explore the icy moons of Jupiter. The project had two major objectives: 1) to develop a nuclear reactor that would provide unprecedented levels of power and show that it could be processed safely and operated reliably in space for long-duration, deep-space exploration; and 2) to explore the three icy moons of Jupiter - Callisto, Ganymede, and Europa - and return science data that would meet the scientific goals as set forth in the Decadal Survey Report of the National Academy of Sciences. Early in project planning, it was determined that the development of the Prometheus nuclear-powered spaceship would be complex and require the intellectual knowledge residing at numerous organizations across the country. In addition, because of the complex nature of the project and the multiple partners, approaches beyond those successfully used to manage a typical JPL project would be needed. This describes the key experiences in managing Prometheus, which should prove useful for future projects of similar scope and magnitude.