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We consider the problem of joint space-time decoding and multiaccess interference (MAI) rejection in multiuser multiple-input multiple-output (MIMO) wireless communication systems. We address the case when both the receiver and multiple transmitters are equipped with multiple antennas and when space-time block codes (STBCs) are used to send the data simultaneously from each transmitter to the receiver. A new linear receiver structure is developed to decode the data sent from the transmitter-of-interest while rejecting MAI, self-interference, and noise. The proposed receivers are designed by minimizing the output power subject to constraints that zero-force self-interference and/or preserve a unity gain for all symbols of the transmitter-of-interest. Simulation results show that in multiaccess scenarios, the proposed techniques have substantially lower symbol error rates as compared with the matched filter (MF) receiver, which is equivalent to the maximum likelihood (ML) space-time decoder in the point-to-point MIMO communication case.