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GCRM (Group Control of Road Machine) system is a new research field for use of multi-agent system (MAS). In order to design a well-defined and easily implemented system based on MAS, there are some problems in system design. In this paper, general issues and special issues about design of a multi-agent system are all concerned. In general issues, architectural problem, coordination and negotiation mechanism and communication mechanism are common components for any scheme of multi-agent system. In special issues, an agent-based supply chain is specially designed in the GCRM system according to the system needs. An agent design considering human factors is put forward. As a result, we investigate some design guidelines from this work.