Multistart optimisation algorithm for joint spatial and kineticparameter estimation in dynamic ECT
Maltz, J.S.
Polak, E.
Budinger, T.F.
Centre for Functional Imaging, Lawrence Berkeley Lab., CA;
This paper appears in: Nuclear Science Symposium, 1998. Conference Record. 1998 IEEE
Publication Date: 1998
Volume: 3,
On page(s): 1567-1573 vol.3
Meeting Date: 11/08/1998 - 11/14/1998
Location: Toronto, Ont., Canada
ISBN: 0-7803-5021-9
References Cited: 13
INSPEC Accession Number: 6359011
Digital Object Identifier: 10.1109/NSSMIC.1998.773842
Current Version Published: 2002-08-06
Abstract
Presents a multistart optimisation algorithm for the joint
estimation of spatial and kinetic parameters for dynamic emission
computed tomography (ECT) studies in which tomographic projections are
sampled serially in time. Parameter estimation is effected using a
projected descent algorithm which refines initial parameter states
generated stochastically via simulated annealing. The exponential
kinetics of the compartmental model are approximated using an orthogonal
basis set which reduces the dimensionality of the parameter space and
addresses the problem of the non-uniqueness of exponential sums. The
algorithm produces encouraging results when used to fit a five
elliptical region single compartment model to the sinogram (obtained
over a single camera rotation) of a dynamic phantom
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