A silicon-based ultrasonic immunoassay for detection of breastcancer antigens
Wang, A.W.
Kiwan, R.
White, R.M.
Ceriani, R.L.
Berkeley Sensor & Acuator Center, California Univ., CA;
This paper appears in: Solid State Sensors and Actuators, 1997. TRANSDUCERS '97 Chicago., 1997 International Conference on
Publication Date: 16-19 Jun 1997
Volume: 1,
On page(s): 191-194 vol.1
Meeting Date: 06/16/1997 - 06/19/1997
Location: Chicago, IL, USA
ISBN: 0-7803-3829-4
References Cited: 8
INSPEC Accession Number: 5751666
Digital Object Identifier: 10.1109/SENSOR.1997.613615
Current Version Published: 2002-08-06
Abstract
We report on a silicon-based immunosensor package that has direct
application to the diagnostic detection of a breast cancer antigen in
the sera of breast cancer patients. We couple the flexural plate wave
(FPW) gravimetric sensor with a novel mass-amplifying label that
increases sensor signal level (a shift of resonant frequency) from that
of previous acoustic immunoassays, in which frequency shifts were due
solely to the weight of the immunoglobulins. The use of a gravimetric
immunoassay with a mass-amplifying label provides an alternative to
radioimmunoassay, eliminating the need for radioactive labels that
require costly disposal
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