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Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort
Carmichael, O.T. Thompson, P.M. Dutton, R.A. Lu, A. Lee, S.E. Lee, J.Y. Kuller, L.H. Lopez, O.L. Aizenstein, H.J. Meltzer, C.C. Yanxi Liu Toga, A.W. Becker, J.T.
Dept. of Neurology, California Univ., Davis, CA;

This paper appears in: Biomedical Imaging: Nano to Macro, 2006. 3rd IEEE International Symposium on
Publication Date: 6-9 April 2006
On page(s): 315-318
Location: Arlington, VA,
ISBN: 0-7803-9576-X
INSPEC Accession Number: 9054317
Digital Object Identifier: 10.1109/ISBI.2006.1624916
Current Version Published: 2006-05-08

Abstract
We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials

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