Welcome to IEEE Xplore 2.0: Holographic sensors in contact lenses for minimally-invasive glucose measurements

Cart | Sitemap | Help

Abstract


	BROWSE	SEARCH	IEEE XPLORE GUIDE	SUPPORT

View TOC

Holographic sensors in contact lenses for minimally-invasive glucose measurements
Domschke, A. Kabilan, S. Anand, R. Caines, M. Fetter, D. Griffith, P. James, K. Karangu, N. Smith, D. Vargas, M. Zeng, J. Hussain, A. Xiaoping Yang Blyth, J. Mueller, A. Herbrechtsmeier, P. Lowe, C.R.
Diagnostic Lens SBU, CibaVision, GA, USA;

This paper appears in: Sensors, 2004. Proceedings of IEEE
Publication Date: 24-27 Oct. 2004
On page(s): 1320- 1323 vol.3
ISBN: 0-7803-8692-2
INSPEC Accession Number: 8486811
Digital Object Identifier: 10.1109/ICSENS.2004.1426425
Current Version Published: 2005-05-09

Abstract
A contact lens with an incorporated glucose-sensitive hologram has been designed as a system for non-invasive measurement of glucose levels in diabetic patients. The hologram consists of an acrylamide copolymer hydrogel with phenylboronic acid groups acting as reversible glucose-binding ligands, allowing dynamic changes in glucose to be detected. The colour of white light reflected off the hologram changes as glucose binds to the phenylboronic acid groups, and this change is used to quantify glucose concentrations. Holograms containing the ligand 3-acrylamidophenylboronic acid (3-APB) were incorporated into a contact lens. The lens was chemically extracted to render it non-toxic. After sterilization through autoclaving, the system still maintained its ability to bind glucose reversibly.

Index Terms
Available to subscribers and IEEE members.

References
Available to subscribers and IEEE members.

Citing Documents
Available to subscribers and IEEE members.

You are not logged in.

Guests may access Abstract records free of charge.