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We report on various aspects of cell adhesion of fibrolasts over densely-populated sharp-tip nano-post structures, which we term “ NanoTurf”. The ability to control the size, shape, and aspect ratio of the nanostructures enabled the study on the effect of surface three-dimensionality of the cell-matrix adhesion in detail. To our best knowledge, this is the first systematic investigation of the nanometric three-dimensional surface topography effect on cell adhesions.
Date of Conference: 2006