Multiscale models of angiogenesis
Qutub, A.A.
Mac Gabhann, F.
Karagiannis, E.D.
Vempati, P.
Popel, A.S.
Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA;
This paper appears in: Engineering in Medicine and Biology Magazine, IEEE
Publication Date: March-April 2009
Volume: 28,
Issue: 2
On page(s): 14-31
ISSN: 0739-5175
INSPEC Accession Number: 10558254
Digital Object Identifier: 10.1109/MEMB.2009.931791
Current Version Published: 2009-04-03
Abstract
This article aims to promote integration of angiogenesis-related models, both integration of the work described herein and many other existing and future models. Integration of molecular mechanisms with cell- and organ- level models allows investigators to study angiogenesis from perspectives in time and space that were once unattainable. As new tools develop for the systematic validation, integration, visualization, and adaptation of these models, the field of angiogenesis heralds an era where modeling becomes an essential component of rigorous experimental design and therapeutic advances.
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