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Anatomical Optical Coherence Tomography for Long-Term, Portable, Quantitative Endoscopy
Leigh, M.S.   Armstrong, J.J.   Paduch, A.   Walsh, J.H.   Hillman, D.R.   Eastwood, P.R.   Sampson, D.D.  
Univ. of Western Australia, Crawley;

This paper appears in: Biomedical Engineering, IEEE Transactions on
Publication Date: April 2008
Volume: 55,  Issue: 4
On page(s): 1438-1446
ISSN: 0018-9294
INSPEC Accession Number: 9918801
Digital Object Identifier: 10.1109/TBME.2007.913409
Current Version Published: 2008-03-14

Abstract
In this paper, we report on anatomical optical coherence tomography, a catheter-based optical modality designed to provide quantitative sectional images of internal hollow organ anatomy over extended observational periods. We consider the design and performance of an instrument and its initial intended application in the human upper airway for the characterization of obstructive sleep apnea (OSA). Compared with current modalities, the technique uniquely combines quantitative imaging, bedside operation, and safety for use over extended periods of time with no cumulative dose limit. Our experiments show that the instrument is capable of imaging subjects during sleep, and that it can record dynamic changes in airway size and shape.

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