Systems Analysis of Regulatory Processes Underlying Eukaryotic Gradient Perception
Krishnan, J.
Iglesias, P.A.
Imperial Coll. London, London;
This paper appears in: Automatic Control, IEEE Transactions on
Publication Date: Jan. 2008
Volume: 53,
Issue: Special Issue
On page(s): 126-138
ISSN: 0018-9286
INSPEC Accession Number: 9747899
Digital Object Identifier: 10.1109/TAC.2007.911358
Current Version Published: 2008-01-22
Abstract
This paper analyzes regulatory processes involved in the biological process of directed cell locomotion - known as chemotaxis. We focus on the nature of regulation involved in a subprocess of chemotaxis called gradient perception. We examine two different models from a dynamics/control perspective to gain insight into the working mechanisms of these models. One model is a minimal model which reconciles gradient perception to the property of adaptation. The second model is a biochemical model of a lipid network and its regulation by enzymes. In both cases, we focus on the extent of regulation of the modules/networks by inputs, and examine various limiting cases. Both the models and the resulting insights have broader applicability than the context in which they were developed.
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