Feedback regulation of the heat shock response in E. coli
Kurata, H.
El-Samad, H.
Yi, T.-M.
Khammash, M.
Doyle, J.
Dept. of Biochem. Sci. & Eng., Kyushu Inst. of Technol.;
This paper appears in: Decision and Control, 2001. Proceedings of the 40th IEEE Conference on
Publication Date: 2001
Volume: 1,
On page(s): 837-842 vol.1
Meeting Date: 12/04/2001 - 12/07/2001
Location: Orlando, FL, USA
ISBN: 0-7803-7061-9
References Cited: 14
INSPEC Accession Number: 7190369
Digital Object Identifier: 10.1109/.2001.980210
Current Version Published: 2002-08-07
Abstract
Survival of organisms in extreme conditions has necessitated the
evolution of stress response networks that detect and respond to
environmental changes. Among the extreme conditions that cells must face
is the exposure to higher than normal temperatures. In this paper, we
propose a detailed biochemical model that captures the dynamical nature
of the heat-shock response in Escherichia coli. Using this model, we
show that both feedback and feedforward control are utilized to achieve
robustness, performance, and efficiency of the response to the heat
stress. We discuss the evolutionary advantages that feedback confers to
the system, as compared to other strategies that could have been
implemented to get the same performance
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