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Čerenkov radiation imaging as a method for quantitative measurements of beta particles in a microfluidic chip
Cho, J.S. Douraghy, A. Olma, S. Liu, K. Chen, Y.C. Shen, C.K. Silverman, R.W. van Dam, R.M. Chatziioannou, Arion F.
UCLA School of Medicine, Department of Pharmacology, Crump Institute at 700 Westwood Plaza, Los Angeles, CA, 90095-1770, USA;

This paper appears in: Nuclear Science Symposium Conference Record, 2008. NSS '08. IEEE
Publication Date: 19-25 Oct. 2008
On page(s): 4510-4515
Location: Dresden, Germany,
ISSN: 1082-3654
ISBN: 978-1-4244-2714-7
Digital Object Identifier: 10.1109/NSSMIC.2008.4774293
Current Version Published: 2009-02-06

Abstract
This work proposes a novel method for quantitative imaging of radioactivity on microfluidic chips by using visible light emission from Čerenkov radiation. Čerenkov radiation is generated when charged particles travel through an optically transparent material with a velocity greater than that of light in that material. It has been observed at UCLA that microfluidic chips used for ¹⁸F-related radio-synthesis studies have shown unidentified visible light emissions. In this study, the origin of the light was investigated and its feasibility as a quantitative imaging source was tested.

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