Treatment interruptions to decrease risk of resistance emerging during therapy switching in HIV treatment
Zurakowski, R.
Wodarz, D.
Univ. of Delaware, Newark;
This paper appears in: Decision and Control, 2007 46th IEEE Conference on
Publication Date: 12-14 Dec. 2007
On page(s): 5174-5179
Location: New Orleans, LA,
ISSN: 0191-2216
ISBN: 978-1-4244-1497-0
INSPEC Accession Number: 9885985
Digital Object Identifier: 10.1109/CDC.2007.4434887
Current Version Published: 2008-01-21
Abstract
The development of multi-drug resistant strains of HIV remains the primary reason for treatment failure and progression to AIDS in the United States. The failure of a particular multi-drug regimen necessitates a switch to a new multi-drug regimen. We use a simple model of the interaction of resistant strains to show that the transition to the new regimen involves a significant risk of strains resistant to the new regimen emerging, and that treatment interruptions using the failing regimen can be used to decrease this risk.
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