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A Geometric Representation of Protein Sequences
Shengyin Gu   Poch, O.   Hamann, B.   Koehl, P.  
Univ. of California, Davis;

This paper appears in: Bioinformatics and Biomedicine, 2007. BIBM 2007. IEEE International Conference on
Publication Date: 2-4 Nov. 2007
On page(s): 135-142
Location: Fremont, CA,
ISBN: 978-0-7695-3031-4
INSPEC Accession Number: 9882698
Digital Object Identifier: 10.1109/BIBM.2007.22
Current Version Published: 2008-01-02

Abstract
The amino acid sequence of a protein is the key to understanding its structure and ultimately its function in the cell. This paper addresses the fundamental issue of encoding amino acids in ways that the visualization of protein sequences facilitates the decoding of its information content. We show that a feature-based representation in a three-dimensional (3D) space derived from substitution matrices provides an adequate representation from which the domain content of a protein can be predicted. In addition, we show that each dimension of the feature space can be related to a physical property of the amino acids.

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