Diode Opening Switch Based Nanosecond High Voltage Pulse Generators for Biological and Medical Applications
Tao Tang
Fei Wang
Kuthi, A.
Gundersen, M.A.
Univ. of Southern California, Los Angeles;
This paper appears in: Dielectrics and Electrical Insulation, IEEE Transactions on
Publication Date: Aug. 2007
Volume: 14,
Issue: 4
On page(s): 878-883
Location: Xi'an, China,
ISSN: 1070-9878
INSPEC Accession Number: 9624346
Digital Object Identifier: 10.1109/TDEI.2007.4286519
Current Version Published: 2007-08-08
Abstract
Studies of short (few ns) pulse cell electroperturbation require high-voltage nanosecond pulses delivered to low-impedance (10 Omega) electroporation cuvette loads. Here we present two pulse generators for these applications. The generators comprise of three stages of pulse modulation: an LC resonant stage switched by IGBT/MOSFET; a magnetic pulse compression stage; and a diode opening switch output stage. The all-solid-state design results in reproducible pulses and reliable, long-life operation. Pulses produced by the LC resonant stage are compressed using nonlinear properties of the magnetic material. The compressed pulses are fed to the diode opening switch, which is constructed by series and parallel connecting ordinary automotive rectifying diodes. Two versions of the pulse generator are described: The first version is capable of generating 20 ns wide, 4.5 kV amplitude pulses of 20 Hz repetition rate. A second version generates 5 ns, 7.5 kV amplitude pulses into the same 10 Omega cuvette load.
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