Compact Subnanosecond Pulse Generator Using Avalanche Transistors for Cell Electroperturbation Studies
Krishnaswamy, P.
Kuthi, A.
Vernier, P.T.
Gundersen, M.A.
Univ. of Southern California, Los Angeles;
This paper appears in: Dielectrics and Electrical Insulation, IEEE Transactions on
Publication Date: Aug. 2007
Volume: 14,
Issue: 4
On page(s): 873-877
Location: Xi'an, China,
ISSN: 1070-9878
INSPEC Accession Number: 9606447
Digital Object Identifier: 10.1109/TDEI.2007.4286518
Current Version Published: 2007-08-08
Abstract
Research on the electroperturbation effects of ultrashort high field pulses in cancer cells requires subnanosecond rise time, high voltage pulses delivered to low impedance biological loads. Here we present a compact solid-state pulse generator developed for this application. The pulse is generated by switching a chain of avalanche transistors configured as a tapered transmission line from high voltage to ground. The system features a built in 1400:1 capacitively compensated resistive voltage divider. The divider, with a 3 dB point at 910 MHz, overcomes challenges in the direct measurement of the high frequency components of the output pulse. The generator is capable of producing a 0.8 ns rise time, 1.3 ns wide, 1.1 kV pulse into a 50 Omega load at a maximum repetition rate of 200 kHz. Techniques to implement physical layouting strategies to achieve subnanosecond rise times are outlined. Problems faced in integrating the subnanosecond pulse generator with a biological load are discussed. This pulse generator will be used in experiments aimed at electromanipulation of intracellular biomolecular structures.
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