Microdialysis Glucose Sensor System Compared With Needle Type Glucose Sensor In Vivo During OGTT And Physical Exercise
Moon, B.U.
Wientjes, K.J.C.
Schoonen, A.J.M.
Groningen Univ., Groningen;
This paper appears in: Sensors, 2006. 5th IEEE Conference on
Publication Date: 22-25 Oct. 2006
On page(s): 1000-1003
Location: Daegu,
ISSN: 1930-0395
ISBN: 1-4244-0376-6
INSPEC Accession Number: 9718430
Digital Object Identifier: 10.1109/ICSENS.2007.355793
Current Version Published: 2007-05-07
Abstract
The 'subcutaneous glucose monitoring system' (SCGM) is based on microdialysis and allows continuous glucose monitoring in abdominal adipose tissue of diabetic patients up to 5 days. In the current in vivo study we compared the SCGM system with a commercially available needle type glucose sensor during an oral glucose tolerance test (OGTT) and during physical exercise. The SCGM had a good in vivo performance that was comparable to the needle type sensor. The inherent safe measuring technology of microdialysis and sensor stability of the SCGM makes it a likely candidate for online glucose measurement in diabetic patients. However, the overall system configuration is too bulky to wear comfortably and the measured values have a time lag of 35 min. The SCGM system will be the base for the future development of a miniaturized integrated microdialysis sensor system using lab-on-a-chip technology.
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