Implantable biomedical microsystems for neural prostheses
Stieglitz, T.
Schuetter, M.
Koch, K.P.
Lab. of Biomedical Microtechnology, Inst. of Microsystem Technol., Freiburg, Germany;
This paper appears in: Engineering in Medicine and Biology Magazine, IEEE
Publication Date: Sept.-Oct. 2005
Volume: 24,
Issue: 5
On page(s): 58- 65
ISSN: 0739-5175
INSPEC Accession Number: 8607624
Digital Object Identifier: 10.1109/MEMB.2005.1511501
Current Version Published: 2005-09-26
Abstract
In the following article, the technologies to fabricate polyimide-based thin and flexible substrates with monolithically integrated electrode arrays and printed circuit boards (PCB) for hybrid electronic assemblies as well as an assembling technique that connects bare electronic dice with flexible PCBs are presented. The concept of modular, flexible biomedical microsystems as neural prostheses is introduced in general and described in detail in three examples. A cuff electrode with integrated multiplexer circuitry and standard implantable cables represents the combination of microtechnology with precision mechanics; a sieve electrode used as an implant in peripheral nerve regeneration studies demonstrates the next level of integration density but still uses a cable connection; and last, joint effort to fabricate the demonstrator of a vision prosthesis that is completely implantable in the eye with a wireless link for energy supply and data transmission is presented. System design, hybrid assembling technology, and flexible multilayer encapsulation using parylene and silicone rubber are the key components for creating a new generation of neural prostheses for complex and challenging new applications.
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