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Information security is always a major problem for administrators and computer professionals in MIS (management information systems). It is becoming more severe, especially in today's networked environments. Either the manager or the computer professional staff have exhausted various methods for solving this problem. Generally speaking, information security is a composite and systematic problem, which should be considered from every aspect of MIS. Besides controlling data access on the database, we need to plan overall, from system network level to MIS application level, and to formulate a complete MIS system security control strategy. The article presents a study of MIS system security based on the client/server architecture. It gives the data and system security strategies and methods in database, computer network, and MIS application levels.