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The kinetics and mechanics of cell adhesion molecules

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3 Author(s)
Cheng Zhu ; Sch. of Mech. Eng., Georgia Inst. of Technol., Atlanta, GA, USA ; Ping Li ; Williams, T.E.

A unifying theory for the molecular biomechanics of receptor-ligand interaction is being developed, which is based on the probabilistic formulation for kinetics of small systems plus the constitutive laws describing the dependence of kinetic rates on force. A diverse set of experiments were performed to test the theory, including those using various cells and molecules, being conducted under both steady and transient conditions, and employing different techniques including centrifugation, micropipette, and rosetting. Specific solutions to each experiment were obtained, many of which are analytical. The satisfactory comparisons between predictions and data not only validate the theory but also enable determination of the constitutive equations and the associated parameters

Published in:

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint  (Volume:2 )

Date of Conference:

Oct 1999