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(Non)stationarity of temporal dynamics in fMRI

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3 Author(s)
V. Calhoun ; Div. of Psychiatric Neuro-Imaging, Johns Hopkins Univ., Baltimore, MD, USA ; T. Adali ; G. Pearlson

Estimation of the temporal information encoded in the observed hemodynamic response in functional MRI (fMRI) is of great interest. One assumption that most of the current studies make is that the mean waveform observed is consistently locked with the stimulus and variably distributed about its mean. Because the noise is high any violations of this assumption are not easily observed. The authors have developed a method for filtering and tracking the hemodynamic response using a recursive least squares (RLS) algorithm and probabilistic shift maps (psm). The authors' initial results clearly demonstrate an overall change in the amplitude from greater to lesser and a latency shift from shorter to longer in primary visual cortex. These changes may indicate fatigue or adaptation of the neuronal patterns or blood supply. The fact that one observes a change in primary visual cortex is notable since this suggests that changes in brain regions which are specialized for higher cognitive functions may exhibit even larger changes. This suggests the importance of determining the degree to which the measured brain region adapts to the paradigm presented in an fMRI experiment

Published in:

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint  (Volume:2 )

Date of Conference:

Oct 1999