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In vitro and in vivo calcification of Nafion membrane used for implantable biosensors

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2 Author(s)
Moussy, F. ; Center for Biomater., Connecticut Univ. Health Center, Farmington, CT, USA ; Mercado, R.C.

The effect of the biological environment on the perfluorosulfonated ionomer Nafion membrane was investigated. The surface topography and surface composition of thermally annealed Nafion membranes were assessed for up to 4 weeks under both in vitro and in vivo conditions. Nafion membranes kept in culture medium or implanted subcutaneously in rats showed extensive cracking. An analysis of surface composition and a fluorescent dye for Ca2+ showed an important deposit of calcium phosphates in the membrane. This deposit caused the membranes to crack. This study indicated that Nafion may not be a suitable material for implantable biosensors unless it is modified to prevent mineralization

Published in:

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE  (Volume:6 )

Date of Conference:

30 Oct-2 Nov 1997

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