By Topic

Use of laser interferometry for evaluation of static characteristics of a microelectrode-positioning system

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
M. Asfour ; Lab. d'Instrum. Micro-Inf. et Electron., Univ. Joseph Fourier, Grenoble, France ; P. -Y. Gumery ; E. Novakov ; H. Roux-Buisson

In an already published work (M. Asfour et al., “Single cell volume measurement using a computer controlled patch-clamp electrode displacement”, in the l8th Annual international conference of the IEEE Engng. in Med. and Biol. Soc., 31 Oct.-3 Nov. 1996, Amsterdam, The Netherlands.), the authors described a motor-driven hydraulic micromanipulator for patch-electrode positioning control with a theoretical resolution of 0.16 μm. That was the first stage aimed to do noninvasive measurements of modulation in a single endothelial cell volume using the patch-clamp equipment. In this paper, which can be considered a continuation of the first one, the authors specially examined static performances of this system using a Michelson interferometer. They determined the experimental value of the resolution (0.142±0.01 μm) and showed the existence of repeatable hysteresis characteristics and a nonlinear portion in the real position of the electrode. The relationship between the position of the electrode and the resistance of the liquid interface cell-micropipette can give changes in the cell height

Published in:

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE  (Volume:6 )

Date of Conference:

30 Oct-2 Nov 1997