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Measurement of myocardial conductivities with a four-electrode technique in the frequency domain

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3 Author(s)
Le Guyader, P. ; Inst de Gen. Biomed., Ecole Polytech., Montreal, Que., Canada ; Savard, Pierre ; Trelles, F.

Bidomain conductivities are evaluated from extracellular measurements on canine myocardial tissue with a modified four-electrode technique. The probe consists of two orthogonal rows of four electrodes with a suitable spacing for sampling the intracellular and interstitial conductivities. A subthreshold sinusoidal current (12 Hz to 2400 Hz) is applied to the outermost electrodes of one row. Potential difference is measured between the innermost electrodes. A drug with uncoupling properties is injected and modifications in conductivities are detected after injection. The longitudinal and transverse potential measurements are fitted with a numerical three dimensional bidomain model with no restriction on the longitudinal to transverse anisotropy ratio

Published in:

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE  (Volume:6 )

Date of Conference:

30 Oct-2 Nov 1997