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The analysis of nonideal effects allows us to derive precise equivalent circuits and models for the different CMOS modulators building blocks. This chapter shows how these models can be used for improving the accuracy and computational efficiency of system-level simulations. It first describes the systematic top-down/bottom-up synthesis methodology commonly followed to design Ms. Then, it compares the different simulation approaches that can be used for the evaluation of Ms, emphasizing on the benefits of behavioral simulation techniques. Next, it focuses on the behavioral modeling technique, and shows an efficient way of implementing M block models in SIMULINK. Finally, the chapter presents SIMulink-based SIgma-DElta simulator (SIMSIDES), a time-domain behavioral simulator implemented in the MATLAB/SIMULINK environment that is based on the behavioral modeling techniques. Two case studies are described to illustrate the use of SIMSIDES for the high-level sizing and simulation of Ms.