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A novel differential filter with ultra-wideband (UWB) response is proposed in this letter based on microstrip line structures. 180° UWB phase shifters and 360° transmission lines are employed in the design to get the 180° phase shift over broad bandwidth. In this way, the broadband conversion between in- and out-of-phase signals can be realized. Utilizing this characteristic, the undesired common-mode noises will be cancelled out at the center of the filter, while the input differential-mode signals can still propagate well. The proposed new differential filter was calculated by transmission line model, simulated by full-wave electromagnetic simulator, and validated by the measurement. The simulation and measurement results verify its good performance. It is validated that, in the proposed filter, the differential-mode signals can propagate well with UWB frequency response, while the common-mode noises are well suppressed with more than 10 dB suppression in the concerned frequency band.