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This paper presents a prototype machine-to-machine (M2M) healthcare solution that combines mobile and IPv6 techniques in a wireless sensor network to monitor the health condition of patients and provide a wide range of effective, comprehensive, and convenient healthcare services. A low-power embedded wearable sensor measures the health parameters dynamically, and is connected, according to the concept of IPv6 over low-power wireless personal area network, to the M2M node for wireless transmission through the internet or external IP-enabled networks via the M2M gateway. A visualization module of the server program graphically displays the recorded biomedical signals on Android mobile devices used by patients and doctors at the end of the networks in real-time. Our approach for a global M2M healthcare solution is managed to process the large amount of biomedical signals through the extended network combining IPv6 technique and mobile technology for daily lifestyle to users appropriately.