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In Cyber-Physical Systems large numbers of heterogeneous cyber and physical subsystems are networked, are interacting tightly, may change dynamically and may expand or contract. Designing and preserving properties of a CPS over its lifespan is very challenging. Passivity and dissipativity are energy like concepts that offer great promise in guaranteeing properties, such as stability, in complex heterogeneous interconnected systems that are changing dynamically. Passivity indices that provide a measure of the degree of passivity are used to generalize classical results in interconnected systems, and results for continuous, discrete and switched systems in networks with delays, event triggered architectures, conic systems and systems with symmetries are shown.