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Detection of Transplant Rejection Chemokine Protein Biomarker in Physiological Salt Concentration

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6 Author(s)
Tulip, F.S. ; Univ. of Tennessee, Knoxville, TN, USA ; Eteshola, E. ; Desai, S. ; Mostafa, S.
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Monokine induced by interferon gamma (MIG) is an important biomarker for early monitoring of transplant rejection. This letter presents a novel technique for detecting human MIG by using immunologically-modified field effect transistors. Detection of MIG with anti-MIG antibody in high concentration phosphate buffer saline solution was achieved for the first time. To provide specific MIG detection capability, anti-MIG IgG molecular affinity interface receptors were formed on a short self-assembled monolayer on a floating gold sensing gate of a biochemically modified AlGaN/GaN high electron mobility transistor device.

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Sensors Journal, IEEE  (Volume:13 ,  Issue: 2 )