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The analysis and characterization of biomedical image data is a complex procedure involving several processing phases, such as data acquisition, preprocessing, segmentation, feature extraction, and classification. The proper combination and parameterization of the utilized methods are heavily relying on the given image dataset and experiment type. They may thus necessitate advanced image processing and classification knowledge and skills from the side of the biomedical expert. In this study, an application, exploiting web services and applying ontological modeling, is presented, to enable the intelligent creation of image-mining workflows. The described tool can be directly integrated to the RapidMiner, Taverna or similar workflow management platforms. A case study dealing with the creation of a sample workflow for the analysis of kidney biopsy microscopy images is presented to demonstrate the functionality of the proposed framework.