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The lossless coding mode of the High Efficiency Video Coding (HEVC) main profile that bypasses transform, quantization, and in-loop filters is described. Compared to the HEVC nonlossless coding mode with the smallest quantization parameter value (i.e., 0 for 8-b video and -12 for 10-b video), the HEVC lossless coding mode provides perfect fidelity and an average bit-rate reduction of 3.2%-13.2%. It also significantly outperforms the existing lossless compression solutions, such as JPEG2000 and JPEG-LS for images as well as 7-Zip and WinRAR for data archiving. To further improve the coding efficiency of the HEVC lossless mode, a sample-based angular intra prediction (SAP) method is presented. The SAP employs the same prediction mode signaling method and the sample interpolation method as the HEVC block-based angular prediction, but uses adjacent neighbors for better intra prediction accuracy and performs prediction sample by sample. The experimental results reveal that the SAP provides an additional bit-rate reduction of 1.8%-11.8% on top of the HEVC lossless coding mode.