The Chemoton: A Model for the Origin of Long RNA Templates.

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$15 $15
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, books, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)

How could genomes have arisen? Two models based on Ganti's Chemoton are presented which demonstrate that under increasingly realistic assumptions, template replication is facilitated without the need of enzymes. It can do this because the template state is stoichiometrically coupled to the cell cycle. The first model demonstrates that under certain kinetic and environmental conditions there is an optimal template length, i.e. one which facilitates fastest replication of the Chemoton. This is in contradiction to previous findings by Csendes who claimed that longer templates allowed more rapid replication. In the second model, hydrogen bonding, phosphodiester bonding and template structure is modeled, so allowing dimer and oligomer formation, hydrolysis and elongation of templates. Here, monomer concentration oscillates throughout the cell cycle so that double strands form at low monomer concentrations and separate at high monomer concentrations. Therefore, this simulation provides evidence that a protocell with Chemoton organization is a plausible mechanism for the formation of long templates, a notorious problem for studies of the origin of life.