By Topic

Phenotypic Variability in Canalized Developmental Systems

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$15 $15
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)

The evolution of nervous systems has been relatively conservative despite a large diversity of behavior. Novel behaviors appear to be produced during evolution by changing synaptic connectivity (Edwards and Palka 1991, Shaw and Meinertzhagen 1986, and Nishikawa et al. 1992). Due to a process of canalization, in which the development of organisms becomes buffered against genetic and environmental changes, phenotypic variation is reduced (Waddington 1942). Therefore, we explore phenotypic variability in simulations of neural development in which the developmental pathways have become canalized. Variation is determined under point mutations and gene knockouts. Although a genetic regulatory network utilizing activation and controlling a single process of neural development is evolvable and can become canalized, large genetic perturbations do not result in increased phenotypic variability as expected from related work (Bergman and Siegal 2003).