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Bioinformatics is the core of biotechnology. Sequence alignment is the most basic and important operation of bioinformatics. The information of functions, structure and evolution in biological sequence can be found by sequence comparison. The basic operation of sequence alignment is comparison. This article describes the common kinds of pair-wise sequence alignment algorithm, and explains them in detail combined with instances. It finally points out the current problems of sequence alignment algorithm.
Date of Conference: 24-27 June 2012