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The results of a fundamental study on developing a general criticality criterion for driving situations are presented. The meaning of criticality in driving situations is defined and the influencing parameters are analyzed. Furthermore, a maneuver-based lane change assistance system is presented and evaluated in subject tests. The outcomes of the general top-down approach are compared to an evaluation criterion which is the available reaction time for the maneuver-based lane change assistance system, developed in a bottom-up approach.